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Gastrointestinal Stromal Tumor: Current Approaches and Future Directions in the Treatment of Advanced Disease.

Hematology/oncology clinics of North America - 1 Aug 2025

Cicala Carlo M, Bauer Sebastian, Heinrich Michael C, Serrano César

Abstract excerpt

This review discusses the current and future landscape of advanced gastrointestinal stromal tumor (GIST) treatment. It covers the role of tyrosine kinase inhibitors (TKIs), specifically imatinib, and further treatment options, such as sunitinib, regorafenib, and ripretinib, as well as avapritinib for platelet-derived growth factor receptor alpha D842V mutations. In addition, this review emphasizes individualized...

Topics

Humans
Gastrointestinal Stromal Tumors
Protein Kinase Inhibitors
Gastrointestinal Neoplasms
Mutation
Molecular Targeted Therapy
Proto-Oncogene Proteins c-kit
Antineoplastic Agents
Imatinib Mesylate

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Identifiers

PMID: 40368739
DOI: 10.1016/j.hoc.2025.04.006
PMCID: PMC12416134

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KIT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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