Precision therapeutic strategies for advanced gastrointestinal stromal tumors.

Abstract excerpt

Gastrointestinal stromal tumors (GISTs), the most common mesenchymal neoplasms of the gastrointestinal tract, are molecularly heterogeneous diseases rather than a single entity. Activating mutations in KIT and PDGFRA define the dominant biological dependencies and establish tyrosine kinase inhibition as a therapeutic backbone. Imatinib, followed by later-line tyrosine kinase inhibitors, including sunitinib,...

Topics

• Humans
• Gastrointestinal Stromal Tumors
• Precision Medicine
• Proto-Oncogene Proteins c-kit
• Molecular Targeted Therapy
• Gastrointestinal Neoplasms