Cystic fibrosis: a disease of altered protein folding.

Abstract excerpt

Cystic fibrosis (CF) is caused by mutations in the gene that encodes the cystic fibrosis transmembrane conductance regulator, CFTR. Previously we demonstrated that the common delta F508 mutation in the first nucleotide binding domain (NBD1) alters the ability of the domain to fold into a function...

Topics

• ATP-Binding Cassette Transporters
• Cystic Fibrosis
• Cystic Fibrosis Transmembrane Conductance Regulator
• Humans
• Mutation
• Protein Folding