Article

Single-molecule dissection of CFTR folding defects and pharmacological rescue

2026-01-27

Abstract excerpt

Cystic fibrosis is a lethal genetic disorder caused by misfolding of the CFTR protein, most commonly due to the ΔF508 mutation. Despite extensive study, CFTR’s folding process has remained inaccessible to direct observation. Here, we apply single-molecule magnetic tweezers to resolve the complete folding trajectories of wild-type and ΔF508 CFTR with near–amino acid resolution. We find that CFTR follows a hierarchi...

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Literature Corpus work: c0050d76-b5dc-5a9a-b493-c5899bc38fc5
DOI: 10.64898/2026.01.26.701897

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