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Article

Structure basis of CFTR folding, function and pharmacology.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Mar 2023

Hwang Tzyh-Chang, Braakman Ineke, van der Sluijs Peter, Callebaut Isabelle

Abstract excerpt

The root cause of cystic fibrosis (CF), the most common life-shortening genetic disease in the Caucasian population, is the loss of function of the CFTR protein, which serves as a phosphorylation-activated, ATP-gated anion channel in numerous epithelia-lining tissues. In the past decade, high-throughput drug screening has made a significant stride in developing highly effective CFTR modulators for the treatment...

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Source

Identifiers

PMID: 36216744
DOI: 10.1016/j.jcf.2022.09.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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