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Article

RAB19, SERPINB9P1, and Pancreatitis in Patients Taking Azathioprine in Routine Clinical Practice: Genome and Transcriptome-Wide Association Studies.

Clinical pharmacology and therapeutics - 1 Oct 2025

Shah Shailja C, Reese Tyler S, Daniel Laura L, Zanussi Jacy, Dickson Alyson L, Nepal Puran, Tao Ran, Miller-Fleming Tyne, Straub Peter, Maizel Jennifer, Hung Adriana M, Wei Wei-Qi, Phillips Elizabeth J, Cox Nancy J, Stein C Michael, Feng QiPing, Chung Cecilia P

Abstract excerpt

Azathioprine is used to treat several inflammatory and autoimmune diseases. However, its use is limited by serious adverse events, including acute pancreatitis. Prior studies have found an association between the HLA region and thiopurine-induced acute pancreatitis (TIAP); however, in clinical practice, many patients with pancreatitis do not meet this strict criterion. We aimed to identify additional genes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40698913
DOI: 10.1002/cpt.70003
PMCID: PMC12439014

Genes

RAB19

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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