Article
Gene polymorphisms involved in manifestation of leucopenia, digestive intolerance, and pancreatitis in azathioprine-treated patients.
Digestive diseases and sciences - 1 Sept 2012
Wroblova Katerina, Kolorz Michal, Batovsky Marian, Zboril Vladimir, Suchankova Jana, Bartos Milan, Ulicny Boris, Pav Igor, Bartosova Ladislava
Abstract excerpt
BACKGROUND: Approximately 10-28 % of patients experience adverse drug reactions related to treatment with thiopurines. The most serious reaction is myelosuppression, typically manifested as leucopenia, which occurs in approximately 2-5 % of patients. Other adverse drug reactions that often accompany thiopurine therapy are pancreatitis, hepatotoxicity, allergic reactions, digestive intolerance, arthralgia, febrile...
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