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Article

Risk factors for serious adverse effects of thiopurines in patients with Crohn's disease.

Current drug safety - 1 Jul 2013

Mazor Yoav, Koifman Eduard, Elkin Hela, Chowers Yehuda, Krivoy Norberto, Karban Amir, Efrati Edna

Abstract excerpt

PURPOSE: Thiopurines are effective in attaining and maintaining remission in patients with inflammatory bowel diseases (IBD). The major drawback of these drugs are their serious adverse effects (SAE), highlighting the importance of preemptive identification of patients at risk. We aimed to examine whether gene polymorphisms in GSTM1, GSTT1 and TPMT, combined with various clinical parameters, can predict...

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Share to Chemical and Drug Induced Liver Injury
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23845145
DOI: 10.2174/15748863113089990033

Genes

GSTM1
GSTT1
TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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