Article

Transiently structured head domains control intermediate filament assembly

2020-03-29

Abstract excerpt

<h4>Summary</h4> Low complexity (LC) head domains 92 and 108 residues in length are, respectfully, required for assembly of neurofilament light (NFL) and desmin intermediate filaments (IFs). As studied in isolation, these IF head domains interconvert between states of conformational disorder and labile, β-strand-enriched polymers. Solid state nuclear magnetic resonance (ss-NMR) spectroscopic studies of NFL and de...

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Literature Corpus work: 253b4785-4caf-50d1-ba16-8855e3d1a13f
DOI: 10.1101/2020.03.27.012112

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