Article

Solid state NMR characterization of wild-type and mutant GFAP intermediate filament assemblies

2026-05-18

Abstract excerpt

GFAP is a type III intermediate filament primarily found within astrocytes and is known to maintain proper cell structure and mechanical strength. Mutations in GFAP are implicated in the pathology of Alexander disease, a neurodegenerative disease characterized by cytoplasmic inclusions of protein, known as Rosenthal fibers. GFAP has a typical type III intermediate filament domain structure, consisting of a highly...

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Literature Corpus work: 9d142363-7226-5d07-a16c-2ec8870b5fb2
DOI: 10.64898/2026.05.15.725530

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