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Article

Experimental characterization of disordered and ordered aggregates populated during the process of amyloid fibril formation.

Proceedings of the National Academy of Sciences of the United States of America - 12 May 2009

Carulla Natàlia, Zhou Min, Arimon Muriel, Gairí Margarida, Giralt Ernest, Robinson Carol V, Dobson Christopher M

Abstract excerpt

Recent experimental evidence points to intermediates populated during the process of amyloid fibril formation as the toxic moieties primarily responsible for the development of increasingly common disorders such as Alzheimer's disease and type II diabetes. We describe here the application of a pulse-labeling hydrogen-deuterium (HD) exchange strategy monitored by mass spectrometry (MS) and NMR spectroscopy (NMR)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19416886
DOI: 10.1073/pnas.0812227106
PMCID: PMC2683116

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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