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Article

Dynamic equilibrium between closed and partially closed states of the bacterial Enzyme I unveiled by solution NMR and X-ray scattering.

Proceedings of the National Academy of Sciences of the United States of America - 15 Sept 2015

Venditti Vincenzo, Schwieters Charles D, Grishaev Alexander, Clore G Marius

Abstract excerpt

Enzyme I (EI) is the first component in the bacterial phosphotransferase system, a signal transduction pathway in which phosphoryl transfer through a series of bimolecular protein-protein interactions is coupled to sugar transport across the membrane. EI is a multidomain, 128-kDa homodimer that has been shown to exist in two conformational states related to one another by two large (50-90°) rigid body domain...

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Identifiers

PMID: 26305976
DOI: 10.1073/pnas.1515366112
PMCID: PMC4577164

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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