Article

Evaluating the cost-effectiveness of polygenic risk score-stratified screening for abdominal aortic aneurysm

2023-11-03

Abstract excerpt

As the heritability of abdominal aortic aneurysm (AAA) is high and AAA partially shares genetic architecture with other cardiovascular diseases, there is interest in whether genetic information could inform AAA screening strategies. Exploiting pleiotropy and meta-analysing summary data from large AAA studies, we constructed a polygenic risk score (PRS) for AAA. Compared with the low PRS tertile, the intermediate a...

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Literature Corpus work: 253b1f29-a5a2-5957-bd40-696fa7b4d43f
DOI: 10.1101/2023.11.02.23297906

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