Article
Polygenic Risk Score Informed Clinical Model for Improving Abdominal Aortic Aneurysm Screening.
Annals of vascular surgery - 1 Dec 2024
Jiang David, Shi Zhuqing, Wei Jun, Tran Huy, Zheng S Lilly, Xu Jianfeng, Lee Cheong J
Abstract excerpt
BACKGROUND: Abdominal aortic aneurysm (AAA) is a complex disease with environmental and genetic risk factors. Polygenic risk scores (PRSs) based on disease-specific risk-associated single nucleotide variants (SNVs) have demonstrated effectiveness in stratifying individual-level disease risk for cardiovascular diseases. This prospective cohort study assessed associations of PRS of AAA (PRSAAA) with risk of...
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