Article

Using a polygenic score to account for genomic risk factors in a model to detect individuals with dilated ascending thoracic aortas

2023-09-08

Abstract excerpt

<h4>Background</h4> Ascending thoracic aortic dilation is a complex trait that involves modifiable and non-modifiable risk factors and can lead to thoracic aortic aneurysm and dissection. Clinical risk factors have been shown to predict ascending thoracic aortic diameter. Polygenic scores (PGS) are increasingly used to assess clinical risk for multifactorial diseases. The degree to which a PGS can improve aortic d...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 757893e6-0cd7-5742-814a-49b35d4012c4
DOI: 10.1101/2023.09.06.23295145

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Using a polygenic score to account for genomic risk factors in a model to detect individuals with dilated ascending thoracic aortasDOI 10.1101/2023.09.06.23295145Read

AORTA Gene: Polygenic prediction improves detection of thoracic aortic aneurysmSemantic proximity Read

Using Machine Learning to Elucidate the Spatial and Genetic Complexity of the Ascending AortaSemantic proximity Read

Predicting thoracic aortic dissection in a diverse biobank using a polygenic risk scoreSemantic proximity Read

Predicting Thoracic Aortic Dissection in a Diverse Biobank Using a Polygenic Risk ScoreSemantic proximity Read

High heritability of ascending aortic diameter and multi-ethnic prediction of thoracic aortic disease.Semantic proximity Read

Novel Polygenic Risk Score and Established Clinical Risk Factors for Risk Estimation of Aortic Stenosis.Semantic proximity Read

Deep learning enables genetic analysis of the human thoracic aortaSemantic proximity Read

Polygenic Risk Score Informed Clinical Model for Improving Abdominal Aortic Aneurysm Screening.Semantic proximity Read

Comparative Performance of Polygenic Risk Scores for Atherosclerotic Cardiovascular Disease Subtypes in the<i>All of Us</i>Research ProgramSemantic proximity Read

Genome-First Approach to Rare and Common Variant Risk of Thoracic Aortic Aneurysm and DissectionSemantic proximity Read

Polygenic Susceptibility of Aortic Aneurysms Associates to the Diameter of the Aneurysm Sac: the Aneurysm-Express Biobank CohortSemantic proximity Read

Prevalence of Genetic Variants and Deep Phenotyping of Patients with Thoracic Aortic Aneurysm and Dissection: A Cross-Sectional Single Centre Cohort StudySemantic proximity Read