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Article

Evaluating the cost-effectiveness of polygenic risk score-stratified screening for abdominal aortic aneurysm.

Nature communications - 14 Sept 2024

Kelemen M, Danesh J, Di Angelantonio E, Inouye M, O'Sullivan J, Pennells L, Roychowdhury T, Sweeting M J, Wood A M, Harrison S, Kim L G

Abstract excerpt

As the heritability of abdominal aortic aneurysm (AAA) is high and AAA partially shares genetic architecture with other cardiovascular diseases, genetic information could help inform AAA screening strategies. Exploiting pleiotropy and meta-analysing summary data from large studies, we construct a polygenic risk score (PRS) for AAA. Leveraging related traits improves PRS performance (R2) by 22.7%, relative to...

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Share to Aortic Aneurysm, Abdominal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39277617
DOI: 10.1038/s41467-024-52452-w
PMCID: PMC11401842

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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