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Article

Weighing the evidence on costs and benefits of polygenic risk-based approaches in clinical practice: A systematic review of economic evaluations.

American journal of human genetics - 7 Aug 2025

Siena Leonardo Maria, Baccolini Valentina, Riccio Marianna, Rosso Annalisa, Migliara Giuseppe, Sciurti Antonio, Isonne Claudia, Iera Jessica, Pierri Francesco, Marzuillo Carolina, De Vito Corrado, La Torre Giuseppe, Villari Paolo

Abstract excerpt

Polygenic risk scores (PRSs) represent a promising innovation in the context of precision health, but their benefits for patients and healthcare systems remain unclear. This systematic review examined the methods used to quantify the costs and benefits of PRS-based approaches across different healthcare contexts, summarizing current evidence and identifying challenges. A systematic search of three databases was...

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Identifiers

PMID: 40513564
DOI: 10.1016/j.ajhg.2025.05.012
PMCID: PMC12414691

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