Article

Remodeling of the core leads HIV-1 pre-integration complex in the nucleus of human lymphocytes

2020-01-25

Abstract excerpt

Retroviral replication proceeds through obligate integration of the viral DNA into the host genome. To enter the nucleus, the viral DNA must be led through the nuclear pore complex (NPC). During HIV-1 cytoplasmic journey, the viral core acts like a shell to protect the viral genetic material from antiviral sensors and ensure an adequate environment for the reverse transcription. However, the relatively narrow size...

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Identifiers and source

Literature Corpus work: 25370427-e00f-5007-bf7f-a21280bfb088
DOI: 10.1101/2020.01.24.918383

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