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Article

Quantitative microscopy of functional HIV post-entry complexes reveals association of replication with the viral capsid

17 Dec 2014

Abstract excerpt

The steps from HIV-1 cytoplasmic entry until integration of the reverse transcribed genome are currently enigmatic. They occur in ill-defined reverse-transcription- and pre-integration-complexes (RTC, PIC) with various host and viral proteins implicated. In this study, we report quantitative detection of functional RTC/PIC by labeling nascent DNA combined with detection of viral integrase. We show that the viral...

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PMID: 25517934
DOI: 10.7554/elife.04114

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