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May I Help You with Your Coat? HIV-1 Capsid Uncoating and Reverse Transcription

28 Jun 2024

Abstract excerpt

The human immunodeficiency virus type 1 (HIV-1) capsid is a protein core formed by multiple copies of the viral capsid (CA) protein. Inside the capsid, HIV-1 harbours all the viral components required for replication, including the genomic RNA and viral enzymes reverse transcriptase (RT) and integrase (IN). Upon infection, the RT transforms the genomic RNA into a double-stranded DNA molecule that is subsequently...

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PMID: 39000271
DOI: 10.3390/ijms25137167

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