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The Role of Capsid in HIV-1 Nuclear Entry

22 Jul 2021

Abstract excerpt

HIV-1 can infect non-dividing cells. The nuclear envelope therefore represents a barrier that HIV-1 must traverse in order to gain access to the host cell chromatin for integration. Hence, nuclear entry is a critical step in the early stages of HIV-1 replication. Following membrane fusion, the viral capsid (CA) lattice, which forms the outer face of the retroviral core, makes numerous interactions with cellular...

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PMID: 34452291
DOI: 10.3390/v13081425

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