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Intraplacental injection of human iPSC-derived PDX1+ pancreatic progenitors prolongs Pdx1-deficient mice survival

2024-05-10

Abstract excerpt

<h4>Summary</h4> Interspecies chimeras comprising human tissues have potential for use in disease modeling and regenerative medicine. Here, we successfully transplanted human induced pluripotent stem cell (iPSC)-derived PDX1+ pancreatic progenitor cells into Pdx1 -deficient mouse embryos via intraplacental injection. The engrafted human cells predominantly localized to the duodenum, produced insulin, and extende...

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Literature Corpus work
24bcb4cd-6092-51fd-b56e-567a72fb64bb
DOI
10.1101/2024.05.09.593461
Open publication

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Intraplacental injection of human iPSC-derived PDX1+ pancreatic progenitors prolongs Pdx1-deficient mice survivalDOI 10.1101/2024.05.09.593461
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