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Article

Prolonged estrogen deprivation triggers a broad immunosuppressive phenotype in breast cancer cells.

Molecular oncology - 1 Jan 2022

Hühn Daniela, Martí-Rodrigo Pablo, Mouron Silvana, Hansel Catherine, Tschapalda Kirsten, Porebski Bartlomiej, Häggblad Maria, Lidemalm Louise, Quintela-Fandino Miguel, Carreras-Puigvert Jordi, Fernandez-Capetillo Oscar

Abstract excerpt

Among others, expression levels of programmed cell death 1 ligand 1 (PD-L1) have been explored as biomarkers of the response to immune checkpoint inhibitors in cancer therapy. Here, we present the results of a chemical screen that interrogated how medically approved drugs influence PD-L1 expression. As expected, corticosteroids and inhibitors of Janus kinases were among the top PD-L1 downregulators. In addition,...

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Identifiers

PMID: 34392603
DOI: 10.1002/1878-0261.13083
PMCID: PMC8732350

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