Article

Unliganded Progesterone Receptor Governs Estrogen Receptor Gene Expression by Regulating DNA Methylation in Breast Cancer Cells

2017-09-23

Abstract excerpt

Breast cancer prognosis and response to endocrine therapy strongly depends on the expression of the estrogen and progesterone receptors (ER and PR, respectively). Although much is known about ER α gene ( ESR1 ) regulation after hormonal stimulation, how it is regulated in hormone-free condition is not fully understood. We used ER-/PR-positive breast cancer cells to investigate the role of PR in ESR1 regulation...

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Literature Corpus work: 24b5c3a9-dadc-519d-910d-f33312e1c299
DOI: 10.1101/192567

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