Article
ESR1 gene promoter region methylation in free circulating DNA and its correlation with estrogen receptor protein expression in tumor tissue in breast cancer patients.
BMC cancer - 4 Feb 2014
Martínez-Galán Joaquina, Torres-Torres Blanca, Núñez María Isabel, López-Peñalver Jesús, Del Moral Rosario, Ruiz De Almodóvar José Mariano, Menjón Salomón, Concha Angel, Chamorro Clara, Ríos Sandra, Delgado Juan Ramón
Abstract excerpt
BACKGROUND: Tumor expression of estrogen receptor (ER) is an important marker of prognosis, and is predictive of response to endocrine therapy in breast cancer. Several studies have observed that epigenetic events, such methylation of cytosines and deacetylation of histones, are involved in the complex mechanisms that regulate promoter transcription. However, the exact interplay of these factors in transcription...
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