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Article

Single CpG site methylation controls estrogen receptor gene transcription and correlates with hormone therapy resistance.

The Journal of steroid biochemistry and molecular biology - 1 Jul 2017

Tsuboi Kouki, Nagatomo Takamasa, Gohno Tatsuyuki, Higuchi Toru, Sasaki Shunta, Fujiki Natsu, Kurosumi Masafumi, Takei Hiroyuki, Yamaguchi Yuri, Niwa Toshifumi, Hayashi Shin-Ichi

Abstract excerpt

Hormone therapy is the most effective treatment for patients with estrogen receptor α-positive breast cancers. However, although resistance occurs during treatment in some cases and often reflects changed estrogen receptor α status, the relationship between changes in estrogen receptor α expression and resistance to therapy are poorly understood. In this study, we identified a mechanism for altered estrogen...

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Identifiers

PMID: 28412323
DOI: 10.1016/j.jsbmb.2017.04.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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