Article
Estrogen receptors: new perspectives in breast cancer management.
The Journal of steroid biochemistry and molecular biology - 1 Jun 1994
Petrangeli E, Lubrano C, Ortolani F, Ravenna L, Vacca A, Sciacchitano S, Frati L, Gulino A
Abstract excerpt
The imbalance between proliferative and differentiative estrogenic effect, caused by quantitative and qualitative alteration of the estrogen receptor (ER) expression, may play a determinant role in mammary neoplastic transformation. Our studies demonstrate that ER levels are significantly higher in human mammary neoplastic tissues when compared to perineoplastic tissues and that increased ER expression is...
Topics
- Breast Neoplasms
- Female
- Genetic Therapy
- Humans
- Mutation
- Receptors, Estrogen