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Article

A New Role for ERα: Silencing via DNA Methylation of Basal, Stem Cell, and EMT Genes

16 Nov 2016

Abstract excerpt

Abstract Resistance to hormonal therapies is a major clinical problem in the treatment of estrogen receptor α–positive (ERα+) breast cancers. Epigenetic marks, namely DNA methylation of cytosine at specific CpG sites (5mCpG), are frequently associated with ERα+ status in human breast cancers. Therefore, ERα may regulate gene expression in part via DNA methylation. This hypothesis was evaluated using a panel of...

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PMID: 28108626
DOI: 10.1158/1541-7786.mcr-16-0283

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