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Article

Altered transcriptome-proteome coupling indicates aberrant proteostasis in Parkinson’s disease

4 Jan 2023

Abstract excerpt

Aberrant proteostasis is thought to be implicated in Parkinson's disease (PD), but patient-derived evidence is scant. We hypothesized that impaired proteostasis is reflected as altered transcriptome-proteome correlation in the PD brain. We integrated transcriptomic and proteomic data from prefrontal cortex of PD patients and young and aged controls to assess RNA-protein correlations across samples. The aged brain...

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PMID: 36711240
DOI: 10.1016/j.isci.2023.105925

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