Article

ASTN2 modulates synaptic strength by trafficking and degradation of surface proteins

2018-06-04

Abstract excerpt

Surface protein dynamics dictate synaptic connectivity and function in neuronal circuits. ASTN2 , a gene disrupted by copy number variations (CNVs) in neurodevelopmental disorders, including autism spectrum, was previously shown to regulate the surface expression of ASTN1 in glial-guided neuronal migration. Here, we demonstrate that ASTN2 binds to and regulates the surface expression of multiple synaptic proteins...

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Literature Corpus work: 5ef9ccb2-75c4-5aef-bf52-0e8969008056
DOI: 10.1101/337618

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