Article

Mechanical forces at the kidney filtration barrier govern spatial orientation of podocyte processes on capillaries

2023-02-10

Abstract excerpt

<h4>ABSTRACT</h4> Mammalian kidneys filter enormous volumes of water and small solutes, a filtration driven by the very high hydrostatic pressure in glomerular capillaries. Interdigitating cellular processes of podocytes form the slits for fluid filtration. They are connected by the membrane-like slit diaphragm cell junction containing a mechanosensitive ion channel complex and allow filtration while counteractin...

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Literature Corpus work: 244ac9f5-e15b-5be8-9f6b-5e40367d8f67
DOI: 10.1101/2023.02.10.528006

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