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Revisiting nephrin signaling and its specialized effects on the uniquely adaptable podocyte

1 Jun 2025

Abstract excerpt

Nephrin is a transmembrane Ig-like domain-containing protein that serves as a central structural and signaling scaffold in kidney filtration. First identified in 1998 as mutated in congenital nephrotic syndrome, the recent identification of nephrin autoantibodies in acquired kidney diseases has sparked renewed interest in nephrin biology. In specialized cells known as podocytes, nephrin helps establish and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40457651
DOI: 10.1042/bcj20230234

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