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Three dimensional multiscalar neurovascular nephron connectivity map of the human kidney across the lifespan

3 Jun 2025

Abstract excerpt

The human kidney maintains homeostasis through a complex network of up to a million nephrons, its fundamental tissue units. Using innovative tissue processing and light sheet fluorescence microscopy, we mapped the 3D neurovascular connectivity of nephrons to understand how their structural organization enables coordinated functions like filtration, absorption, and blood pressure regulation. Our analysis revealed...

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PMID: 40461472
DOI: 10.1038/s41467-025-60435-8

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