Article
A molecular mechanism explaining albuminuria in kidney disease.
Nature metabolism - 1 May 2020
Butt Linus, Unnersjö-Jess David, Höhne Martin, Edwards Aurelie, Binz-Lotter Julia, Reilly Dervla, Hahnfeldt Robert, Ziegler Vera, Fremter Katharina, Rinschen Markus M, Helmstädter Martin, Ebert Lena K, Castrop Hayo, Hackl Matthias J, Walz Gerd, Brinkkoetter Paul T, Liebau Max C, Tory Kálmán, Hoyer Peter F, Beck Bodo B, Brismar Hjalmar, Blom Hans, Schermer Bernhard, Benzing Thomas
Abstract excerpt
Mammalian kidneys constantly filter large amounts of liquid, with almost complete retention of albumin and other macromolecules in the plasma. Breakdown of the three-layered renal filtration barrier results in loss of albumin into urine (albuminuria) across the wall of small renal capillaries, and is a leading cause of chronic kidney disease. However, exactly how the renal filter works and why its permeability is...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.