Article
Podocyte injury elicits loss and recovery of cellular forces.
Science advances - 1 Jun 2018
Haley Kathryn E, Kronenberg Nils M, Liehm Philipp, Elshani Mustafa, Bell Cameron, Harrison David J, Gather Malte C, Reynolds Paul A
Abstract excerpt
In the healthy kidney, specialized cells called podocytes form a sophisticated blood filtration apparatus that allows excretion of wastes and excess fluid from the blood while preventing loss of proteins such as albumin. To operate effectively, this filter is under substantial hydrostatic mechanical pressure. Given their function, it is expected that the ability to apply mechanical force is crucial to the...
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