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Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems

4 Aug 2014

Abstract excerpt

Hepatitis B virus (HBV) chronically infects 400 million people worldwide and is a leading driver of end-stage liver disease and liver cancer. Research into the biology and treatment of HBV requires an in vitro cell-culture system that supports the infection of human hepatocytes, and accurately recapitulates virus-host interactions. Here, we report that micropatterned cocultures of primary human hepatocytes with...

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PMID: 25092305
DOI: 10.1073/pnas.1412631111

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