Article

Longitudinal monitoring of disease burden and response using ctDNA from dried blood spots in xenograft models

2022-01-18

Abstract excerpt

Whole genome sequencing (WGS) of circulating tumour DNA (ctDNA) is now a clinically important biomarker for predicting therapy response, disease burden and disease progression. However, the translation of ctDNA monitoring into vital pre-clinical PDX models has not been possible owing to low circulating blood volumes in small rodents. Here, we describe the longitudinal detection and monitoring of ctDNA from minute...

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Literature Corpus work: 2432b63c-3c5e-5e07-9d04-820ccd0af982
DOI: 10.1101/2022.01.15.476442

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