The Small GTPase Rab7 Regulates Release of Mitochondria in Extracellular Vesicles in Response to Lysosomal Dysfunction

Abstract excerpt

Mitochondrial quality control is critical for cardiac homeostasis as these organelles are responsible for generating most of the energy needed to sustain contraction. Dysfunctional mitochondria are normally degraded via intracellular degradation pathways that converge on the lysosome. Here, we identified an alternative mechanism to eliminate mitochondria when lysosomal function is compromised. We show that lysosom...

Topics

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• Autophagosomes
• Autophagy
• Disease Management
• Genetic Therapy
• Lysosomal-Associated Membrane Protein 2
• Lysosomes
• Membrane Fusion
• Myocytes, Cardiac

Identifiers and source

Literature Corpus work

242b5901-c5cc-5f82-b938-e09ca07bdd3c

DOI

10.1101/2023.02.11.528148