Article

Early endosome disturbance and endolysosomal pathway dysfunction in Duchenne muscular dystrophy

2024-12-18

Abstract excerpt

Duchenne muscular dystrophy (DMD) is a lethal dystrophy characterized by the progressive loss of muscle fibers caused by mutations in DMD gene and absence of the dystrophin protein. While autophagy and lysosome biogenesis defects have been described in DMD muscles, the endosomal pathway has never been studied. Here, we showed that impaired lysosome formation is associated with altered acidification and reduced de...

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Literature Corpus work: 91fd2bd1-00df-54cc-a687-060806a91307
DOI: 10.1101/2024.12.16.628552

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