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Article

Endosomal Rab cycles regulate Parkin-mediated mitophagy

23 Jan 2018

Abstract excerpt

Damaged mitochondria are selectively eliminated by mitophagy. Parkin and PINK1, gene products mutated in familial Parkinson's disease, play essential roles in mitophagy through ubiquitination of mitochondria. Cargo ubiquitination by E3 ubiquitin ligase Parkin is important to trigger selective autophagy. Although autophagy receptors recruit LC3-labeled autophagic membranes onto damaged mitochondria, how other...

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PMID: 29360040
DOI: 10.7554/elife.31326

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