Article

RAB7 deficiency impairs pulmonary artery endothelial function and promotes pulmonary hypertension

2023-02-03

Abstract excerpt

<h4>ABSTRACT</h4> Pulmonary arterial hypertension (PAH) is a devastating and progressive disease with limited treatment options. Endothelial dysfunction plays a central role in development and progression of PAH, yet the underlying mechanisms are incompletely understood. The endosome-lysosome system is important to maintain cellular health and the small GTPase RAB7 regulates many functions of this system. Here, w...

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Literature Corpus work: 5aaf37f3-c1e2-51fb-b657-7a0e1af3b34c
DOI: 10.1101/2023.02.03.526842

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