Article

DMC-BH derivative DMC-GF inhibits the growth of glioma stem cells by targeting the TRIM33/SLC25A1/mitochondrial oxidative phosphorylation pathway

2024-11-14

Abstract excerpt

<title>Abstract</title> <p>Glioma stem cells (GSCs) present formidable resistance to conventional radiotherapy and chemotherapy, thereby largely contributing to the high recurrence rates associated with gliomas. There is an urgent unmet clinical need for efficacious targeted therapeutics. Previously, we identified DMC-BH, a derivative of curcumin, exhibiting potent anti-glioma activity both in vitro and in vivo....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2422e34d-627b-5ac9-89af-21b22fcad842
DOI: 10.21203/rs.3.rs-5306321/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DMC-BH derivative DMC-GF inhibits the growth of glioma stem cells by targeting the TRIM33/SLC25A1/mitochondrial oxidative phosphorylation pathwayDOI 10.21203/rs.3.rs-5306321/v1Read

SMYD2 induced PGC1α methylation promotes stemness maintenance of glioblastoma stem cellsSemantic proximity Read

Redox-Regulated Pathways in Glioblastoma Stem-like Cells: Mechanistic Insights and Therapeutic ImplicationsSemantic proximity Read

Effective Elimination of Cancer Stem Cells By a Novel Drug Combination StrategySemantic proximity Read

Verteporfin inhibits oxidative phosphorylation and induces cell death specifically in glioma stem cellsSemantic proximity Read

The Multi-Faceted Effect of Curcumin in Glioblastoma from Rescuing Cell Clearance to Autophagy-Independent EffectsSemantic proximity Read

OMA1 maintains the stemness of glioma stem cells by inducing mitochondrial fission/fusion imbalanceSemantic proximity Read

Mitochondrial damage triggers therapy-induced senescenceSemantic proximity Read

Identification of Compounds That Decrease Glioblastoma Growth and Glucose Uptake <i>in Vitro</i>Semantic proximity Read

A Cytotoxic Three-Dimensional-Spheroid, High-Throughput Assay Using Patient-Derived Glioma Stem CellsSemantic proximity Read

Multi-Omics Analyses Reveal Mitochondrial Dysfunction Contributing to Temozolomide Resistance in Glioblastoma CellsSemantic proximity Read

PGC1α Degradation Suppresses Mitochondrial Biogenesis to Confer Radiation Resistance in GliomaSemantic proximity Read

A multistep in silico approach identifies potential glioblastoma drug candidates via inclusive molecular targeting of glioblastoma stem cellsSemantic proximity Read