Article
Administration of a microRNA-21 inhibitor improves the lupus-like phenotype in MRL/lpr mice by repressing Tfh cell-mediated autoimmune responses.
International immunopharmacology - 1 May 2022
Gao Xiaofei, Song Yang, Du Pei, Yang Shuang, Cui Haobo, Lu Shuang, Hu Longyuan, Liu Limin, Jia Sujie, Zhao Ming
Abstract excerpt
BACKGROUND: Inhibiting Tfh cell overexpansion prevents autoimmune responses and disease flares in systemic lupus erythematosus (SLE). miR-21 is highly expressed in SLE CD4+ T cells, but whether inhibiting miR-21 can reduce Tfh cell expansion and alleviate the disease progression of lupus is unclear. AIM OF THE STUDY: To address the role and molecular mechanism of miR-21 in regulating Tfh cell expansion and its...
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