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Article

FcγRI is the key determinant of antibody-mediated Zika virus infection of human placental macrophages

2025-10-24

Abstract excerpt

<h4>SUMMARY</h4> Zika virus (ZIKV) can be vertically transmitted from a pregnant mother to the developing fetus, resulting in microcephaly and/or other congenital malformations. Dengue virus (DENV) cross-reactive antibodies can facilitate ZIKV placental transcytosis and enhance ZIKV infection of placenta macrophage-Hofbauer cells through binding to Fc-γ receptors (FcγRs). To understand the role of individual FcγR...

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Identifiers and source

Literature Corpus work
23e275c4-8b1a-5304-92e2-cf2788845e19
DOI
10.1101/2025.10.23.684201
Open publication

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FcγRI is the key determinant of antibody-mediated Zika virus infection of human placental macrophagesDOI 10.1101/2025.10.23.684201
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