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Monoclonal Antibodies against Zika Virus NS1 Protein Confer Protection via FcγReceptor-Dependent and -Independent Pathways

8 Feb 2021

Abstract excerpt

Zika virus (ZIKV) is a mosquito-borne flavivirus that has been linked to congenital microcephaly during recent epidemics. No licensed antiviral drug or vaccine is available. Monoclonal antibodies (MAbs) against the nonstructural protein 1 (NS1) inhibit ZIKV pathogenicity but do not enhance the disease as envelope protein-targeted MAbs do. However, the protection mechanisms are not fully understood. Here, we show...

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PMID: 33563822
DOI: 10.1128/mbio.03179-20

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