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Comparative Analysis of In Vitro Models to Study Antibody-Dependent Enhancement of Zika Virus Infection

13 Dec 2022

Abstract excerpt

During the 2015-2016 outbreak of Zika virus (ZIKV) in the Americas, a previously unknown severe complication of ZIKV infection during pregnancy resulting in birth defects was reported. Since the ZIKV outbreak occurred in regions that were highly endemic for the related dengue virus (DENV), it was speculated that antibody-dependent enhancement (ADE) of a ZIKV infection, caused by the presence of cross-reactive...

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PMID: 36560779
DOI: 10.3390/v14122776

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