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The HAVCR1-centric host factor network drives Zika virus vertical transmission

30 Mar 2025

Abstract excerpt

Zika virus (ZIKV) vertical transmission results in devastating congenital malformations and pregnancy complications; however, the specific receptor and host factors facilitating ZIKV maternal-fetal transmission remain elusive. Here, we employ a genome-wide CRISPR screening and identify multiple placenta-intrinsic factors modulating ZIKV infection. Our study unveils that hepatitis A virus cellular receptor 1...

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PMID: 40156834
DOI: 10.1016/j.celrep.2025.115464

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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