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Article

Modulation of Dengue/Zika Virus Pathogenicity by Antibody-Dependent Enhancement and Strategies to Protect Against Enhancement in Zika Virus Infection.

Frontiers in immunology - 1 Jan 2018

Khandia Rekha, Munjal Ashok, Dhama Kuldeep, Karthik Kumaragurubaran, Tiwari Ruchi, Malik Yashpal Singh, Singh Raj Kumar, Chaicumpa Wanpen

Abstract excerpt

Antibody-dependent enhancement (ADE) is a phenomenon in which preexisting poorly neutralizing antibodies leads to enhanced infection. It is a serious concern with mosquito-borne flaviviruses such as Dengue virus (DENV) and Zika virus (ZIKV). In vitro experimental evidences have indicated the preventive, as well as a pathogenicity-enhancing role, of preexisting DENV antibodies in ZIKV infections. ADE has been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29740424
DOI: 10.3389/fimmu.2018.00597
PMCID: PMC5925603

Genes

NOS2
STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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