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Article

Transcriptional Noise and Somatic Mutations in the Aging Pancreas.

Cell metabolism - 5 Dec 2017

Swisa Avital, Kaestner Klaus H, Dor Yuval

Abstract excerpt

The underlying mechanisms and functional significance of pancreatic β cell heterogeneity are an intensive area of investigation. In a recent Cell paper, Enge and colleagues (2017) performed single-cell RNA sequencing of human pancreatic cells and concluded that with age, pancreatic cells become transcriptionally noisy and accumulate somatic mutations.

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Identifiers

PMID: 29211979
DOI: 10.1016/j.cmet.2017.11.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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