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Article

Somatic Mosaicism in Biology and Disease.

Annual review of physiology - 10 Feb 2022

Ogawa Hayato, Horitani Keita, Izumiya Yasuhiro, Sano Soichi

Abstract excerpt

Contrary to earlier beliefs, every cell in the individual is genetically different due to somatic mutations. Consequently, tissues become a mixture of cells with distinct genomes, a phenomenon termed somatic mosaicism. Recent advances in genome sequencing technology have unveiled possible causes of mutations and how they shape the unique mutational landscape of the tissues. Moreover, the analysis of sequencing...

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Identifiers

PMID: 34637327
DOI: 10.1146/annurev-physiol-061121-040048
PMCID: PMC10552082

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